pain pathway flowchart
Pain Pathway Flowchart Example


 Pain Pathway Flowchart
How we become aware of the pain

Pain is not a pleasant feeling. Regardless of how much we try to avoid it, we still suffer from it. So, learning about this topic can help us find optimal solutions to clinical and even neuropathic pain.  

A pain pathway flowchart provides great assistance to explain how and why we are aware of ache. In this blog, you will gain a walk-through of the four-staged process of this feeling.

It provides illuminating insights into how our brain areas communicate with each other and how we perceive the painful feeling! You can explain the effects of mechanical stimuli on the creation of chronic pain.

Overview Of Pain Pathway Flowchart

The improvements of research tools and methods provide more knowledge about nociceptive pain, chronic pain, acute chest pain, acute chest pain, coronary artery disease, etc.

The more we research the neurobiological underpinnings of deep pain, the more treatment we can give for radical solutions to this feeling. It divulges the mechanism of action and which areas we can approach to design a holistic pain treatment.

The following part will explain clearly many terminologies: somatosensory cortex, spinothalamic tracts, sensory neurons, temperature sensation, etc.

 Pain Pathway Flowchart
Overview of pain pathway flowchart

What Is A Pain Pathway?

This pathway is a journey of feeling pain, describing how our brain generates and receives signals. The information gets transmitted from the periphery. Its destination is the cortex through transit at the central nervous system.

There have been experiments on animals and even humans for better understanding such a subtle process. Many potential areas of research, such as neuropathic pain and inflammatory pain, are still being researched and developed.

There have been few comprehensive reports about the impacts of chronic pain on our musculoskeletal system. It also points out the importance of studying the contribution of psychosocial aspects.

Application And Advantages


A pain pathway flowchart reveals the invisible process of pain signaling when the body suffers harmful stimuli. Basic information about the complete steps is expected from this review article.

The more we know about such an undesirable feeling, the more possible it is to develop striking remedies to neuropathic pain (localized pain).

The neural pathways of chronic pain have attracted many researchers to conduct studies. With the aid of this flowchart, we can see how the sensory neurons enhance or restrict signal propagation.

As a result, the medical field will have more effective treatment of this feeling to cutaneous injuries, inflammatory or neuropathic pain, etc.


Learning about this subject is to help humans suffer less from it. The attempts of research about its process can also lead to more effective treatment.

Researchers can use the findings in research about cutaneous pain on animals. It provides a source of references to deep dive into other aspects. The scope of studies becomes broader and deeper!

Pain Pathway Flowchart: Complete Steps

 Pain Pathway Flowchart
4 stages  in the neurophysiologic process

There are four stages in the neurophysiologic process that pain goes through. When learning about its pathway, our brain’s complexity and miracle are under the spotlight.  

It is a natural operation that stimulates or limits its signaling. The connections among brain areas and their working independence are the keys!

In addition, you will explore the subjectivity of pain under the impacts of background stories and personal experiences. The intensity of ache we feel can vary among each other.

Our brain is sensitive to the signals of pain impulses. It has central sensitization, peripheral sensitization, etc.


When we touch hot items, get a fistfight, etc., the nerve endings of nociceptors turn the noxious stimulus into a nerve signal. We can also call it an action potential. The spinothalamic tracts help us collect sensations.

Our temperature sensations, conscious sensations, etc., are sensitive to such stimuli.

Simply put, the whole process will start once the information appears and needs processing. You can consider transduction as an input.


Once the brain gets informed of a painful stimulus, the transmission transfers the signals to the central nervous system. The somatosensory cortex is a place where our brain analyzes these signals.

Reflex arcs of periaqueductal gray are also affected. In addition, the efferent neurons transfer the information to the peripheral nerves for the according actions. So, people tend to respond to noxious stimuli immediately.

There are studies about issues that might happen in receiving signals. The existence of ache cannot be reported to our brain.

For this reason, people might not know that they are suffering painful feelings if their nociceptors do not work.

Pain Modulation

Modulation is a miraculous operation. It modifies how much ache we feel. It regulates the levels of soreness in the brain and the dorsal horn of the spinal cord. The second-order neurons of the cord create the path for pain.

Melzack and Wall improved their knowledge about the gate control theory. It indicated the inhibition of the signals to our consciousness.

Meanwhile, the latest research reports that these signals from our brain can boost or constrain transmission.

The brain can also soothe us down with its available substances. They have the same usage of opiates opioid drugs. So, the painful feelings lose their intensity thanks to our superior brains!

Insights into the spectacular ache modulation can support the applications to psychopharmacology.


It gets interesting because it shows how subjective the painful feeling can be! Along with the power of modulation, life experience and cultural environment are influential factors.

It explains why some people react differently to the same-same noxious stimuli. Perception of this feeling is a complex process in itself. There are three main activities - thinking, expecting, and interpreting.

Interpretation is like the moment we recall our memories and use our belief system to add or eliminate acute ache sensations.

The nuances of pain are various, hence making its measurements challenging. Yet, it has become an interesting area of research!